Approximated analytical characterization of the steady‐state chemical exchange saturation transfer (CEST) signals
نویسندگان
چکیده
منابع مشابه
Analytical determination of the chemical exchange saturation transfer (CEST) contrast in molecular magnetic resonance imaging
Magnetic resonance based on molecular imaging allows tracing contrast agents thereby facilitating early diagnosis of diseases in a non-invasive fashion that enhances the soft tissue with high spatial resolution. Recently, the exchange of protons between the contrast agent and water, known as the chemical exchange saturation transfer (CEST) effect, has been measured by applying a suitable pulse ...
متن کاملWater saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments.
Chemical exchange saturation transfer (CEST) is a contrast mechanism that exploits exchange-based magnetization transfer (MT) between solute and water protons. CEST effects compete with direct water saturation and conventional MT processes, and generally can only be quantified through an asymmetry analysis of the water saturation spectrum (Z-spectrum) with respect to the water frequency, a proc...
متن کاملDetermining the chemical exchange saturation transfer (CEST) behavior of citrate and spermine under in vivo conditions
PURPOSE To estimate the exchange rates of labile (1) H in citrate and spermine, metabolites present in prostatic secretions, to predict the size of the citrate and spermine CEST effects in vivo. METHODS CEST z-spectra were acquired at high-field [11.7 Tesla (T)] from citrate and spermine solutions at physiological pH (6.5) using saturation power 6 μT. CEST was performed at different temperatu...
متن کاملOn the origins of chemical exchange saturation transfer (CEST) contrast in tumors at 9.4 T.
Chemical exchange saturation transfer (CEST) provides an indirect means to detect exchangeable protons within tissues through their effects on the water signal. Previous studies have suggested that amide proton transfer (APT) imaging, a specific form of CEST, detects endogenous amide protons with a resonance frequency offset 3.5 ppm downfield from water, and thus may be sensitive to variations ...
متن کاملNoninvasive MRI of tissue redox state based on endogenous chemical exchange saturation transfer (CEST) contrast
Target audience: Research scientists or clinicians who are interested in cancer metabolism, oxidative stress and redox state. Introduction/Purpose: Cellular redox state has been demonstrated as a key player in cellular biology. The disturbed balance of the redox state, such as excessive oxidative stress, can lead to many pathologic changes including cancer, heart diseases, neurodegenerative dis...
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ژورنال
عنوان ژورنال: Magnetic Resonance in Medicine
سال: 2019
ISSN: 0740-3194,1522-2594
DOI: 10.1002/mrm.27864